Juvenile Chronic Arthritis
In childhood the most frequent rheumatological disease is juvenile rheumatoid arthritis which is also one of the most frequent chronic diseases in this age group. There are a number of different but related disorders which are expressed in chronic inflammation of the joints. It is not clear what causes these conditions and the complexity of the underlying genetic bases for them makes it difficult to clearly distinguish the different types. The naming of the diseases is also under review, with juvenile idiopathic arthritis perhaps gaining ground.
Three main divisions of juvenile rheumatoid arthritis can be described, that affecting many joints which is called polyarticular, that involving few joints and termed pauciarticular and a more body wide disease onset known as systemic arthritis. The arthritis is a chronic disease which flares up at times and then goes into remissions, with targeting of the medical treatment towards the induction and maintenance of a remission. Recent advances in the development of drugs have produced the biological agents which are much more effective for arthritic diseases.
How and why juvenile rheumatoid arthritis develops is not well understood, with an autoimmune attack against the tissues of the joints perhaps precipitated by infection or trauma. The lining of the joint, the synovial membranes, becomes larger and becomes chronically inflamed, with this occurring in individuals with some susceptibility of genetic origin. How the disease presents in the person and how it comes on is under the control of a number of genes. The incidence of these arthritic conditions is variable due to variations in influences from the environment, differences in the populations involved and in how susceptible individuals are.
Approximately fifty percent of all sufferers from juvenile chronic arthritis fall into the oligoarticular type with few joints affected, making it the most common type. With a greater number of joints affected by arthritis, the polyarticular type occurs in about a third of patients, with the remaining patients having the systemic form. Juvenile arthritis patients may be susceptible to acquiring a second autoimmune disorder. The significant disability and pain causes psychological distress, problems with behaviour, depression and anxiety. Girls are more likely to suffer from the many joint affected and poor joint affected forms, with equal incidence in the systemic form.
In terms of age, the few joint (oligoarticular) type occurs most commonly in children of two to four years in age, while the many joint (polyarticular) peaks at one to four years and also at six to twelve years. The systemic type can occur right through the childhood years. The division of juvenile chronic arthritis that a child belongs in is determined by the pattern of onset of the disease over the first six months. If four joints or fewer are involved then the child is classified into the oligoarticular chronic arthritis group. If a child has more than five joints affected in the six month period then they are recognised as being in the polyarticular type. The type which presents with a systemic onset comes on with the arthritis, fever and rashes.
If a diagnosis of juvenile arthritis of some form is to be made then the patient should have arthritis of some of their joints for at least six weeks. Stiffness in the morning or after periods when the joint has been kept still is a typical complaint. The start of the disease can be very sudden and dramatic or may come on slowly over some time, with common symptoms including stiffness of the joints as mentioned, joint pain in the day, periods of absence from school and a limping gait. Some patients also suffer from inflammatory disease of the bowel. A child may not always report actual pain in a joint but instead they may just allow the joint to go unused and develop atrophy or a joint contracture.
In the systemic form of juvenile arthritis the child suffers from fevers which spike once or twice a day at around the same time, the temperature typically returning back to normal each time. This pattern is different from infections so helps to distinguish what the patient is suffering from. These patients usually show a short lasting rash over the trunk and limbs, joint pain often in the bigger joints and appear to be unwell.
Jonathan Blood Smyth, editor of the Physiotherapy Site, writes articles about Physiotherapist, back pain, orthopaedic conditions, neck pain, injury management and Physiotherapists in London. Jonathan is a superintendant physiotherapist at an NHS hospital in the South-West of the UK.
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